Registered Practical Nurse (RPN) Practice Test

If typical and atypical antipsychotic treatments are ineffective, what medication is often considered next?

1. Risperidone

2. Clozapine

3. Aripiprazole

4. Lurasidone

The correct answer is: Clozapine

Clozapine is often considered the next step in treatment for patients experiencing treatment-resistant schizophrenia or those in whom typical and atypical antipsychotic treatments have proven ineffective. This is largely due to its unique mechanism of action that differs from other antipsychotics, which allows it to be effective in cases where other medications have failed. Clozapine has a significant impact on both positive and negative symptoms of schizophrenia, making it a vital option for individuals who have not responded well to other treatments. Additionally, it is known to reduce the risk of suicidal behavior in patients with schizophrenia, which adds another layer of importance to its use in this context. This medication, however, is associated with the risk of agranulocytosis, a serious side effect that necessitates regular monitoring of white blood cell counts. This monitoring requirement can sometimes lead to hesitance in its prescription; nevertheless, when the risk is managed carefully, CLOZAPINE can provide substantial benefits for patients who are otherwise difficult to treat. Understanding the clinical context in which clozapine is utilized solidifies its position as a crucial option for those who have not found relief through other medications.