Registered Practical Nurse (RPN) Practice Test

What is a primary theory regarding the cause of major depression?

1. Psychosocial factors

2. Genetic predisposition

3. Environmental triggers

4. Dietary influences

The correct answer is: Genetic predisposition

The theory that genetic predisposition plays a primary role in the development of major depression is supported by various studies showing that individuals with a family history of depression are more likely to experience depressive episodes themselves. This suggests a biological basis where genetics can influence brain chemistry, neurotransmitter functioning, and overall susceptibility to mood disorders. Research in behavioral genetics indicates that specific genes may contribute to the risk of developing major depression, encompassing various factors, including serotonin transport and regulation. Furthermore, the heritability of depression has been estimated to be significant, underscoring the impact of genetic factors. While psychosocial factors, environmental triggers, and dietary influences can all contribute to the onset and severity of depression, they often interact with underlying genetic vulnerabilities. Therefore, while these factors are important in the comprehensive understanding of depression, the genetic predisposition remains a primary theory supporting the notion that certain individuals are more susceptible to developing this condition due to their biological makeup.