Registered Practical Nurse (RPN) Practice Test

When assessing a client switched to olanzapine (Zyprexa), which history should the nurse specifically inquire about?

1. Recent travel

2. Alcohol use

3. Cigarette smoking

4. History of depression

The correct answer is: Cigarette smoking

When assessing a client who has been switched to olanzapine (Zyprexa), it is particularly important for the nurse to inquire about the client's cigarette smoking history. This is because smoking can significantly affect the metabolism of olanzapine, potentially leading to altered drug levels in the body. Research shows that nicotine can induce liver enzymes that metabolize certain medications, including antipsychotics like olanzapine, which may result in decreased effectiveness of the drug. Therefore, understanding a client's smoking habits is crucial in managing their treatment effectively and ensuring optimal therapeutic outcomes. In contrast, while recent travel, alcohol use, and a history of depression are all relevant aspects of a client's overall health and may play a role in their mental health treatment, they do not have as direct an impact on the pharmacokinetics and pharmacodynamics of olanzapine as cigarette smoking does. Thus, the nurse focuses on the smoking history to tailor the treatment plan appropriately.