Registered Practical Nurse (RPN) Practice Test

Why is it significant for nurses to monitor patients on both SSRIs and tryptophan closely?

1. To evaluate mental health improvements

2. To prevent possible drug overdoses

3. To detect the onset of serotonin syndrome

4. To ensure medication compliance

The correct answer is: To detect the onset of serotonin syndrome

The significance of closely monitoring patients on both SSRIs (Selective Serotonin Reuptake Inhibitors) and tryptophan primarily centers around the risk of developing serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition that can occur when there is excessive serotonergic activity in the nervous system. Since both SSRIs and tryptophan can increase serotonin levels, combining them can elevate the risk of this syndrome. When patients take SSRIs, their serotonin levels are already increased as these medications work by blocking the reuptake of serotonin in the brain, making it more available. Tryptophan is an amino acid that is a precursor to serotonin; therefore, adding it to a treatment regimen involving SSRIs can further increase serotonin levels. The combination can lead to symptoms of serotonin syndrome, such as agitation, increased heart rate, hypertension, confusion, and gastrointestinal disturbances. Due to this risk, nurses need to be vigilant in monitoring their patients for any signs of serotonin syndrome so that prompt medical interventions can occur if needed. This proactive approach ensures patient safety and effective management of their mental health conditions while minimizing the risk of severe complications.