Registered Practical Nurse (RPN) Practice Test

What can long-term use of cocaine followed by its discontinuation lead to, as explained to a client during detoxification?

1. A "high"

2. A "crash" due to norepinephrine depletion

3. Increased anxiety

4. Increased appetite

The correct answer is: A "crash" due to norepinephrine depletion

The correct answer indicates that long-term use of cocaine followed by its discontinuation can lead to a "crash" due to norepinephrine depletion. This is a significant concept in understanding the physiological effects of cocaine on the body. Cocaine is a powerful stimulant that increases the levels of neurotransmitters like norepinephrine, dopamine, and serotonin in the brain while actively being used. When someone stops using cocaine after a period of dependency, the brain experiences a reduction in these neurotransmitters, particularly norepinephrine, which can lead to feelings of severe fatigue and dysphoria commonly referred to as a "crash." This state often involves symptoms like depression, lethargy, and an overwhelming desire to use the drug again to alleviate these negative feelings. Understanding this reaction is crucial for healthcare professionals working with clients undergoing detoxification. It is essential to prepare clients for the possibility of experiencing a "crash" after stopping cocaine use, as this can help them better understand their symptoms and the importance of supportive care during the withdrawal process. Recognizing this physiological response can guide patient education and ongoing support throughout recovery.