Registered Practical Nurse (RPN) Practice Test

What substance is known to cause a state of sensory deprivation and dissociation?

1. Cocaine

2. Ketamine

3. Heroin

4. Alcohol

The correct answer is: Ketamine

Ketamine is known for its unique pharmacological effects, particularly its ability to induce states of sensory deprivation and dissociation. As a dissociative anesthetic, it works primarily by blocking NMDA receptors in the brain, leading to a detachment from one’s sensory experience and environment. This dissociative effect can create feelings of unreality, altered perception of time and space, and a sense of separation from one’s body. Ketamine is often used in medical settings for anesthesia, but its effects on sensory perception make it notable for its use in treating certain mental health conditions, such as depression and PTSD. Other substances listed, like cocaine, heroin, and alcohol, have different mechanisms of action and do not primarily induce dissociative effects in the same manner. Cocaine is a stimulant that primarily increases dopamine levels, leading to heightened alertness and euphoria rather than dissociation. Heroin, an opioid, can lead to sedation and relaxation, but it doesn't typically cause the dissociative experiences associated with ketamine. Alcohol, while it can impair sensory perception and cognitive function, it is not classified as a dissociative agent and does not induce the same level of sensory deprivation. This distinction highlights why ketamine is recognized for its specific ability